M. Dukat, M. Taroua, A. Dahdouh
Jul 16, 2004
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
Several amine-substituted 8-amino-5,6,7,8-tetrahydroisoquinolines were examined as conformationally-constrained analogs of the nicotinic cholinergic (nACh) 3-(aminomethyl)pyridines. Although these ligands failed to bind at nACh receptors, the N-ethyl-N-methyl analog 3d was found to be at least equipotent with nicotine in rodent tests of antinociception. The mechanism of action of 3d is currently unknown.