Sandhya Bawa, R. Kumar, G. Chawla
Jul 23, 2010
Citations
0
Influential Citations
2
Citations
Journal
Molbank
Abstract
Abstract: ( 8-Chloro-3-methyl-1 H -pyrazolo[4,3- c ]cinnolin-1-yl) (pyridin-4-yl)methanone 2 has been synthesized through condensation of 3-acetyl-6-chloro-1 H -cinnolin-4-one 1 with isonicotinic acid hydrazide (INH) in absolute ethanol. The structure of the title compound 2 was established on the basis of IR, 1 H-NMR, 13 C-NMR and mass spectral data. Keywords: cinnoline; pyrazole; isonicotinic acid hydrazide Cinnoline is a benzfused pyridazine containing two nitrogen atoms at 1,2-position and it is categorized under benzfused diazines class of heterocyclic compounds. Literature shows several compounds containing a cinnoline moiety with a wide spectrum of pharmacological activities, like antimicrobial, anti-inflammatory, anticancer, antimalarial and antipsychotic etc. [1–5]. As a part of research on benzfused heterocyclic compounds [6], we report here the synthesis of ( 8-chloro-3-methyl-1 H -pyrazolo[4,3- c ]cinnolin-1-yl) (pyridin-4-yl)methanone