Liu Shuhua
2010
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Journal
Occupation and Health
Abstract
8-iso-prostaglandin F2α is a kind of prostaglandin isomers,which is produced by nonenzymatic free radical-catalyzed peroxidation of arachidonic acid on the cell membrane,and it is a perfect biological indicator to evaluate the level of oxidative stress(OS) and lipid peroxidation.Kidney is one of the major target organs of damage induced by hypertension,and hypertensive nephropathy and hypertension often form a vicious circle,which is the difficulty of clinical treatment.8-iso-prostaglandin F2α can observantly reflect OS level in vivo when hypertensive nephropathy occurred,and reflect the degree of renal injury further.In this paper,authors will make a review about research progress of correlation between 8-iso-prostaglandin F2α and hypertensive nephropathy.