N. Marmiy, D. Esipov
Aug 1, 2018
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0
Influential Citations
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Journal
Vestnik Volgogradskogo Gosudarstvennogo Universiteta. Serija 11. Estestvennye nauki
Abstract
The study is devoted to 8-oxo-2'-deoxyguanosine (8-oxo-dG), which is used as a biomarker of oxidative damage to DNA and its associated diseases. The study is based on the hypothesis put forward by the authors about the ability of 8-oxo-dG, which is the main product of DNA oxidation, to act as a signal molecule that activates cell resistance to nonspecific stress and DNA repair. In addition to studying the molecular mechanisms of the action of 8-oxo-dG, the authors have carried out an investigation of the effects that they caused on the organism level.