E. Valente, J. Zubkowski, Ken S. Lee
Apr 1, 1997
Citations
0
Influential Citations
9
Citations
Journal
Journal of Chemical Crystallography
Abstract
The synthetic steroid 9α-fluoro-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate (9-fluoroprednisolone-21-acetate), formula C23H29O6F, is related to substances which are potent inducers of hepatic microsomal enzymes and anti-inflammatory agents. The structure was determined at 294 K from counter-collected data by direct methods. Crystals are tetragonal, space groupP41212,a, b=9.214(2),c=49.452(39) Å,V=4198(4), Å,Dx=1.33μg/m3 forZ=8;R (onF) 0.063 for 915 independent intensities (I>2σ1). The structure shows H-bonding and packing of the mean molecular plane approximately perpendicular to the crystallographic 4-fold axis.