L. A. Carpino, H. Chao, M. Beyermann
Apr 1, 1991
Citations
0
Influential Citations
52
Citations
Journal
Journal of Organic Chemistry
Abstract
It is shown in this work that FMOC amino acid chlorides are also applicable to solid-phase syntheses by the simple expedient of in situ conversion to the appropriate N-hydroxybenzotriazole ester via reaction with a 1:1 mixture of HOBt and an appropriate tertiary amine. In cases where acid chlorides are inaccessible due to side-chain incompatibility, pentafluorophenyl esters or BOP-induced couplings represent convenient spot substitutes