Tony Taldone, Pallav D. Patel, Hardik J. Patel
May 16, 2012
Citations
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Influential Citations
9
Citations
Journal
Tetrahedron Letters
Abstract
Abstract In this report we describe a simple synthesis of mercaptobenzonitriles from the reaction of fluorobenzonitriles with Na2S in DMF at room temperature and following direct treatment with Zn/HCl. Significantly, 2- and 4-fluorobenzonitriles substituted with chlorine or bromine, but not iodine, undergo selective substitution of fluorine at room temperature to yield synthetically useful halo-substituted mercaptobenzonitriles.