W. J. Irwin, F. Sanderson, A. Po
Dec 1, 1990
Citations
0
Influential Citations
14
Citations
Quality indicators
Journal
International Journal of Pharmaceutics
Abstract
n-Alkanoic N,N-dimethylamides were found to act as penetration enhancers for the transport of ibuprofen and naproxen from suspensions in 50% aqueous propylene glycol vehicles across rat skin. Stripped skin and separated dermis were used to establish the maximum potential for enhancement and comparisons with established enhancers such as azone and N-methylpyrollidone were undertaken. Greatest enhancement was observed with naproxen but both drugs demonstrated a bell-shaped dependence on the alkyl chain length of the enhancer. Maximum effect was observed with N,N-dimethyloctanamide and N,N-dimethyldecanamide. Measurement of the skin-vehicle partition coefficients indicated that the partition of the drug into the skin was also maximal when these enhancers were incorporated into the vehicle. Permeation studies monitoring the flux of enhancer indicated that these compounds also penetrated the skin most effectively. In contrast, the enhancers had little effect on delivery from liquid paraffin vehicles.