W. Chen, P. Vrindten, P. Dayton
Feb 1, 1962
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Influential Citations
79
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Quality indicators
Journal
Life Sciences
Abstract
Abstract Pretreatment of human subjects for 7 to 11 days with phenylbutazone depresses plasma levels of intravenously administered aminopyrine and elevates those of its metabolite, 4-aminoantipyrine. These results were explained by a stimulatory action of phenybutazone on the metabolism of aminopyrine, an effect which was demonstrated previously in the rat.