T. N. Trinh, A. McCluskey
Jul 27, 2016
Citations
0
Influential Citations
6
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The multicomponent reaction of ethyl 3-aminocrotonate ( 1 ), substituted phenylisothiocyanates ( 2a – i ) and acetic anhydride ( 7 ), afforded facile access to a series of substituted 1,3-thiazine-6-phenylimino-5-carboxylates under mild conditions in 15–65% yields. Limited tolerance for modification of the anhydride moiety was noted with a significant reduction in yield for propionic and trifluoroacetic anhydrides. The use of benzoic anhydride favoured a two-component coupling product.