Shoji Kobayashi, Ami Ando, Hiroyuki Kuroda
Nov 25, 2011
Citations
0
Influential Citations
17
Citations
Journal
Tetrahedron
Abstract
Abstract A practical route to 6-bromo-5,7-dihydroxyphthalide 5-methyl ether, a versatile intermediate in the synthesis of hericenones and related bioactive polyphenols, was developed. The synthesis features a combination of tandem Michael addition-Claisen condensation and CuBr 2 -mediated multi-step reactions. With this product in hand, total syntheses of hericenone J and 5′-deoxohericenone C (hericene A) were achieved.