V. Hélaine, Joël Rossi, J. Bolte
Sep 3, 1999
Citations
0
Influential Citations
14
Citations
Journal
Tetrahedron Letters
Abstract
Abstract 4-Alkyl-2-alkylidene-glutaric acids are easily obtained by a Claisen-Johnson rearrangement, providing a short access to 4-alkyl-α-ketoglutaric acids. These compounds are substrates of the glutamic oxalacetic transaminase (GOT), allowing the enzymatic synthesis of biologically important analogues of l -glutamate. A new analogue, (2S,4R)-4-propyl-glutamic acid, is described.