A. B. Mandal, J. Augustine, A. Quattropani
Sep 5, 2005
Citations
0
Influential Citations
12
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A simple, efficient, and general two-step synthesis to bromo-pyridine carbaldehyde scaffolds is described. This direct route involves sequential reactions employing the dibromination of bromo-picolines followed by hydrolysis using an aqueous solution of calcium carbonate. Bromo-pyridine carbaldehyde scaffolds 1–7 were obtained in good overall yield. Bromo-dibromomethyl-pyridine intermediates have been isolated and characterized.