Ahmad F Kassir, Sherif S. Ragab, Thao M. Nguyen
Oct 3, 2016
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0
Influential Citations
14
Citations
Journal
The Journal of organic chemistry
Abstract
A short synthesis of all four stereoisomers of 3-amino-2-oxetanecarboxylic acid (oxetin) is described. The oxetane core is built using a Paternò-Büchi photochemical [2 + 2] cycloaddition; from the key intermediates, complementary resolution protocols provide access to enantiomerically pure oxetin and epi-oxetin on gram-scale.