C. Reddy, Javed Y. Shaikh, Ramakrishna G. Bhat
Apr 29, 2020
Citations
0
Influential Citations
7
Citations
Journal
The Journal of organic chemistry
Abstract
An efficient and straightforward method has been developed for the synthesis of β-benzyl-substituted five-membered heterocyclic carbaldehydes via transient directing group-enabled direct γ-C(sp3)-H arylation of 3-methylheteroarene-2-carbaldehydes. A wide range of 3-methylheteroarene carbaldehydes undergoes coupling with a variety of aryl iodides including less reactive iodo pyridine derivatives to provide a library of highly selective functionalized products in good to excellent yields. Some of these products have been successfully utilized in synthesizing useful synthetic intermediates.