D. Nilov, A. Kadushkin, I. F. Kerbnikova
Feb 1, 1995
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Journal
Pharmaceutical Chemistry Journal
Abstract
The condensation of diethylacetal of dimethylformamide with 4-amino-5-ethoxycarbonyl-1,2-polymethyleneimidazoles yielded derivatives of 7,8-polymethylenehypoxanthines that are precursors of 6-amino- and 6-alkylmercapto-7,8-polymethylenepurines and 1-substituted-7,8-polymethylenehypoxanthines. On the basis of the latter, 1,2-trimethylene-4,5,7,8-tetrahydro-6H-imidazo[4.5-e][1.4]diazepine-5,8-dione was obtained. The example of 6-substituted purines was used to study the antiviral activity, and 1-substituted purines were used to study the antihypertensive activity.