A. A. Al-badr, H. El-obeid
2005
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Influential Citations
5
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Journal
Profiles of drug substances, excipients, and related methodology
Abstract
Publisher Summary This chapter presents the physical profile of acetylcholine chloride. The empirical formula of the acetylcholine chloride is C 7 H 16 ClNO 2 . Acetylcholine chloride is obtained as white or off-white hygroscopic crystals, or as a crystalline powder. The physical properties includes pH, solubility characteristics, crystallographic properties, thermal methods of analysis, spectroscopy and mass spectrometry are discussed. Acetylcholine chloride is freely soluble in water, alcohol, propylene glycol, and chloroform, and is practically insoluble in ether. Acetylcholine chloride is very hygroscopic and extremely soluble, giving a solution of high viscosity. For this reason, it is difficult to prepare crystals appropriate for X-ray analysis. Aqueous solutions of acetylcholine chloride are found to be unstable. Such solutions are decomposed by heat, and are incompatible with alkalis and acids. The mass spectrum of acetylcholine chloride is obtained utilizing a Shimadzu PQ-5000 mass spectrometer, with the parent ion being collided with helium carrier gas and the mass spectrum and the mass fragmentation pattern is shown in the chapter.