R. R. Roberts, Stephen R. Landor, E. Bolessa
May 9, 1994
Citations
0
Influential Citations
6
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Ethyl alka-2,3-dienoates and 4-tetrahydropyranyloxyalk-2-ynenitriles provide a 3-atom fragment when reacted with acetamidine in tetrahydrofuran, to furnish 2-methylpyrimidin-4(3H)-ones and 4-amino-2-methyl-6-(1-tetrahydropyranyloxyalkyl)pyrimidines, respectively (60 – 70% yield). The latter, with hydrochloric acid / ethanol, gave the corresponding 4-amino-6-(1-hydroxyalkyl-2-methylpyrimidines as their hydrochloride salts.