Hisashi Tanaka, H. Sakurai, A. Yokoyama
May 25, 1970
Citations
0
Influential Citations
10
Citations
Journal
Chemical & Pharmaceutical Bulletin
Abstract
Selenocysteamine (2-aminoethaneselenol) hydrochloride was prepared by three methods. Compositive acid dissociation constants of selenocysteamine were determined by potentiometric titration. Microscopic dissociation constants of cationic, anionic, zwitterionic and neutral forms, and tautomeric constant between zwitterionic and neutral forms were calculated, in selenocysteamine and cysteamine. Selenocysteamine was found to present completely as zwitter-ionic form at pH 7-10, whereas cysteamine was found to present about 60% as zwitter-ionic form at pH 10.