Gaofeng Yuan, A. Sinclair, Ciqin Zhou
Apr 1, 2009
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0
Influential Citations
28
Citations
Quality indicators
Journal
Journal of the Science of Food and Agriculture
Abstract
BACKGROUND: The objective of this study was to investigate the metabolism of α-eleostearic acid (α-ESA, cis9,trans11,trans13-18:3) and punicic acid (PA, cis9,trans11,cis13-18:3) and to compare the relative conversion efficiency of these fatty acids into conjugated linoleic acids (CLAs) in mice. RESULTS: Twenty-four male ICR mice were fed either a control diet or one of two experimental diets supplemented with 10 g kg−1α-ESA or PA in the form of triacylglycerols for 6 weeks. The accumulation of PA in all tissues examined was significantly higher than α-ESA; in both groups it was found that cis9,trans11-conjugated linoleic acid (cis9,trans11-18:2) was detected in all tissues examined. The relative conversion rate of α-ESA into cis9,trans11-18:2 was significantly higher than that of PA. The highest conversion rate of α-ESA was found in adipose tissue (91.8%), spleen (91.4%) and kidney (90.7%), and the lowest in the heart (84.6%). The highest conversion rate of PA occurred in the liver (76.2%) and the lowest occurred in the heart (54.5%). CONCLUSION: The present results indicate that both α-ESA and PA are effectively metabolized into cis9,trans11-18:2 in mice. These conjugated dietary fatty acids might be useful sources of CLAs in tissues owing to the natural abundance of α-ESA and PA in some seeds. Copyright © 2009 Society of Chemical Industry