C. Lorenc, J. Reeves, C. Busacca
Mar 4, 2015
Citations
0
Influential Citations
9
Citations
Journal
Tetrahedron Letters
Abstract
Tertiary amides containing an N-isopropyl group were selectively deprotected by heating in methanesulfonic acid. The N-isopropyl group was removed selectively in the presence of other groups on the amide nitrogen such as methyl, primary alkyl, or aryl. The putative isopropyl cation was trapped by Friedel–Crafts alkylation of anisole when the latter was included as a co-solvent.