A. Visa, B. Maranescu, G. Ilia
2016
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Abstract
In the last decades, the interest in the organophosphorus compound preparation using chlorine-free reagents has been of great importance, due to significant applications of phosphorus compounds as reagents in future synthesis. Usually, organophosphorus derivatives are obtained starting from phosphorus trichloride or phosphoryl chloride, although the final products do not have reactive phosphorus–chlorine bonds. In the last period the interest is to replace the halogen-containing compounds with other starting reagents using environmentally safe paths. In this chapter we tried to summarize the aspects of using hypophosphorous acid and its salts as reagents for organophosphorus compounds. The chapter is focused on the synthesis of α-aminophosphinic acid, α-aminophosphinates, H-phosphinic acids, and H-phosphinates. These reactions are discussed in classical conditions and, as microwave-assisted synthesis, in the presence or absence of metal catalysts or reaction solvents. Phosphonate metal organic frameworks are an important class of materials, which achieves dramatic growth in the last 15 years. Therefore a brief overview of the reactivity of phosphinic acids used to obtain phosphonic acids is provided.