Xiaoyan Sheng, Y. Yung, Allison Chen
Apr 15, 2015
Citations
3
Influential Citations
112
Citations
Quality indicators
Journal
Development
Abstract
Lysophosphatidic acid (LPA) is a bioactive phospholipid that is present in all tissues examined to date. LPA signals extracellularly via cognate G protein-coupled receptors to mediate cellular processes such as survival, proliferation, differentiation, migration, adhesion and morphology. These LPA-influenced processes impact many aspects of organismal development. In particular, LPA signalling has been shown to affect fertility and reproduction, formation of the nervous system, and development of the vasculature. Here and in the accompanying poster, we review the developmentally related features of LPA signalling. SUMMARY: This poster article summarises how lysophosphatidic acid is produced and metabolised during development, how it signals, and how it influences tissue and organ development.