M. Sofia, Floreancig Paul Edward, W. Jackson
Jun 30, 1993
Citations
0
Influential Citations
2
Citations
Quality indicators
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
7-[4-Acetyl-2-ethyl-5-hydroxyphenoxy)propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid sodium salt 7 (LY247826) and several 7-[3-(4-acetyl-2-ethyl-5-hydroxyphenoxy)propoxy)-2-propylphenoxy] acetic acid analogues were prepared as LTB4 receptor antagonists. When compared with LY255283 and SC-41930, these antagonist showed improved in vitro LTB4 receptor antagonism and/or in vivo activity.