Suzuki Takayoshi, M. Takamoto, T. Okamoto
May 25, 1986
Citations
0
Influential Citations
13
Citations
Journal
Chemical & Pharmaceutical Bulletin
Abstract
A number of N, N-dibenzylaminoacetaldehyde diakyl acetales (1) double-cyclized in 70% perchloric acid or triflic acid (trifluoromethanesulfonic acid) to give good yields of 7, 12-dihydro-5H-6, 12-methanodibenz[c, f]azocines (2) even when a powerful electron-withdrawing substituent, for example a nitro group, was present on the benzene ring. Triflic acid treatment of α-dibenzylaminoketones (3) caused double-cyclization to give 12-substituted derivatives of 2.