R. Yamasaki, Saori Fujikake, Ai Ito
Jan 6, 2016
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Influential Citations
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Citations
Journal
Tetrahedron Letters
Abstract
Abstract Amide oligomers composed of pyridine-2-carboxamide as the repeating unit were synthesized in a stepwise manner and their structures were examined by means of 1 H NMR, NOE measurements, and DFT calculations. All the synthesized oligomers adopted a folded conformation, but became partially unfolded at the C-terminal upon addition of acid. A characteristic long-range hydrogen bond, which stabilizes local folding, was present in oligomers with a long main chain.