Lin Yan, R. Budhu, Pei Huo
Jul 1, 2006
Citations
0
Influential Citations
19
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of 2-aryl(pyrrolidin-4-yl)acetic acids were synthesized and their biological activities were evaluated as agonists of S1P receptors. These analogs were able to induce lowering of lymphocyte counts in the peripheral blood of mice and were found to have good overall pharmacokinetic properties in rat.