Y. Hoshina, S. Ikegami, Akihiko Okuyama
Jan 3, 2005
Citations
0
Influential Citations
11
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
The discovery and SAR of 2,3-diphenylpropionic acid derivatives as highly potent VLA-4 antagonists are described. One representative compound, 9cc has inhibited intercellular adhesion by a VCAM-1/VLA-4 interaction with an IC(50) of 1.7 nM, and has good pharmacokinetics and oral bioavailability.