I. Ienascu, A. Lupea, D. Hădărugă
Mar 9, 2008
Citations
0
Influential Citations
10
Citations
Quality indicators
Journal
Revista De Chimie
Abstract
Based on our studies of the biological activity of 2-hydroxybenzamide derivatives, we evaluated the antimicrobial activity of some novel compounds from this class (esters, hydrazides, hydrazones), against bacterial (Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Bacillus cereus) and fungical (Sacharomyces cerevisiae, Candida albicans) strains using the disc-diffusion method under standard conditions. It was found that all tested compounds present a good activity against the tested microorganisms and they were more active against Candida albicans. The established minimum inhibitory concentration (MIC) values were ranged between 10 -2 - 3.6·10 -4 mol/L and were used to obtain some quantitative structurebiological activity relationships using HyperChem 5.01 program for molecular modelling and conformational analysis. The established equations using different parameters present correlation coefficients statistically ensured.