N. Takemura, C. Hashida, M. Terasawa
Nov 1, 1974
Citations
0
Influential Citations
37
Citations
Journal
British Journal of Cancer
Abstract
5-NITROACENAPHTHENE (5-NAN) has been used as an intermediate fluorescent whitening agent and a photochemical agent. From the viewpoint of prevention of occupational cancer, our attention has been focused on the possible carcinogenicity of this chemical. Its chemical structure is shown in the figure. In our previous experiment (Takemura, 1970) myeloid leukaemias, lymphosarcomata or reticulum cell sarcomata were produced in the dd strain female mice that had received this chemical by intraperitoneal injection for a period of 18 months. Further significantresultswereobtained from our present experiment, in which rats and hamsters were given 5-NAN orally.