Y. Cheng, S. Grill, G. Dutschman
Dec 15, 1979
Citations
0
Influential Citations
9
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract The most effective period of 5-propyl deoxyuridine action was 3–6 hr post-infection in both herpes simplex virus type 1- and type 2-infected HeLa BU cells. This antiviral activity could not be reversed by removing the drug from the culture medium. A correlation exists between inhibition of virus growth and inhibition of induction of virus specific DNase and DNA polymerase. No inhibition of induction of virus specific thymidine kinase was observed when virus replication was inhibited by 5-propyl deoxyuridine.