B. Hajjem, M. L. B. Khoud, B. Baccar
Sep 1, 2010
Citations
0
Influential Citations
2
Citations
Journal
Bulletin des Sociétés Chimiques Belges
Abstract
Methyl 3-amino-2-thiophene carboxylate reacts with orthoesters to produce N-(2-carbomethoxy thienyl) imidates 1. Treatment of these imidates with primary amines, hydrazine, methylhydrazine and phenylhydrazine yields only [3,2-d]4(3H)thieno- pyrimidinones 2 and not isomeric 1,3,4-thienotriazepin-5-ones. The type of products obtained gave information relevant to the elucidation of the mechanism of cyclization and the relative activities of the ester and imidate groups.