Nakagawa Hideo, Tsurufuji Susumu
Mar 15, 1972
Citations
0
Influential Citations
17
Citations
Quality indicators
Journal
Biochemical Pharmacology
Abstract
Abstract The mode of action of betamethasone disodium phosphate, a steroidal antiinflammatory drug, on the metabolism of collagen and non-collagen protein in rat carrageenin granuloma was studied. The inhibitory effect of the steroid on the incorporation of [ 3 H]proline into collagen and noncollagen protein was progressively increased with an increase in dose and reached a maximum at a level of 0.2 mg rat . The effect of the steroid on the degradation of collagen and noncollagen protein labeled with [ 3 H]proline was investigated. Betamethasone disodium phosphate inhibited the degradation of collagen in vivo and markedly reduced the amount of dialyzable hydroxyproline formed by the degradation of collagen during incubation of the minced granuloma in vitro . The degradation of noncollagen protein, in contrast with the degradation of collagen, was apparently not affected by the steroid treatment. It seems likely that betamethasone disodium phosphate, a steroidal anti-inflammatory drug, causes the resorption of pre-existing granulomatous tissue through a strong inhibitory action on protein synthesis without apparently affecting the degradation of noncollagen protein, even though the degradation of collagen is inhibited.