Yung‐chi Cheng, B. Domin, R. Sharma
Jul 1, 1976
Citations
1
Influential Citations
94
Citations
Quality indicators
Journal
Antimicrobial Agents and Chemotherapy
Abstract
5-Ethyl-, 5-vinyl-, 5-propyl-, and 5-allyl-2′-deoxyuridine (dUrd) had antiviral activity against herpes simplex type 1 and type 2 grown in HeLa TK− cells, in the order 5-vinyl-dUrd, 5-ethyl-dUrd, 5-propyl-dUrd, 5-allyl-dUrd, but they were inactive against a TK− mutant of herpes simplex type 1. The antiviral activity of these compounds could be partially reversed by thymidine. Except for 5-vinyl-dUrd, they were not toxic to WI-38 and HeLa TK− cells at a concentration of 25 μM. All four analogues inhibited the growth of herpes simplex type 1-transformed HeLa TK− cells at a concentration of 1 μM.