H. King, Jean Wright
Oct 26, 1948
Citations
0
Influential Citations
7
Citations
Journal
Proceedings of the Royal Society of London. Series B - Biological Sciences
Abstract
This communication completes this series of investigations. Ten carbinolamines derived from 6:7-dimethylquinoline and based on the quinine model are described. Three of the substances containing the 2-phenyl-6:7-dimethylquinoline nucleus show antiplasmodial activity on malaria in canaries much superior to the activity of quinine. The 6:7-dimethyi groups present in these compounds show a structural affinity with riboflavin but the antiplasmodial results are not favourable to the view that riboflavin-antagonism plays any significant part in the mechanism of action of these active bases.