K. T. Poroshin, T. D. Kozarenko, V. A. Shibnev
Mar 1, 1960
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Journal
Russian Chemical Bulletin
Abstract
1. The methyl esters of synthetic (benzyloxycarbonyl)glycyl-L-prolyl-L-hydroxyprolyl-glycyl-L-prolyl-L-hydroxyproline, (benzyloxycarbonyl)glycyl-L-prolyl-L-hydroxyprolyl-glycyl-glycyl-L-proline, (benzyloxy-carbonyl)-L-prolyl-glycyl-glycyl-glycyl-L-proline, and (benzyloxycarbonyl)-L-prolyl-DL-alanyl-glycyl-L-proline were found to act as substrates for collagenase. 2. Collagenase may be used also for the hydrolysis of peptides containing only glycine and imino acids. 3. Peptides consisting of alternations of glycylproline or prolylproline are stable to the action of collagenase. 4. In principle, the replacement of an amide group by an ester group in peptides containing four or more amino acid residues has no effect on the substrate activity of the peptides.