V. Doctor
Aug 1, 1972
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Quality indicators
Journal
Thrombosis Research
Abstract
Abstract The mechanism of action of glucuronolactone on the clotting of the recalcified human plasma was investigated. Addition of the compound resulted in inhibition of the clotting of both the glass contacted and the non-contact human plasma in siliconized glass tubes. The results therefore suggest that stage(s) after the contact activation phase of the clotting sequence were influence by the inhibition. At pH's 7.4 or below, glucuronolactone is more inhibitory than at pH's above 7.4. The clot- promoting effects of tissue thromboplastin or thrombin or Russell's viper venom is partially reversed by glucuronolactone indicating that more than one reaction step in the clotting sequence were affected by the compound.