R. Ings, J. McFadzean, W. Ormerod
May 1, 1974
Citations
3
Influential Citations
183
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Radioactivity from 14C-metronidazole was quickly taken from the medium into cells of Trichomonas vaginalis. It was rapidly metabolised by these organisms, largely to one product, by removal of the 5-nitro group. Radioactivity from 14C-metronidazole was also bound to DNA and protein of T. vaginalis but not to RNA. Inhibition of nucleic acid synthesis was demonstrated in both this and other drug-sensitive organisms at drug concentrations as low as 1 μg/ml. A possible mechanism of action of the drug has been postulated.