E. Hendley, S. Snyder
Dec 28, 1968
Citations
1
Influential Citations
106
Citations
Quality indicators
Journal
Nature
Abstract
MONOAMINE oxidase (MAO) inhibitors were the first clinically used antidepressant drugs. Several tricyclic compounds of iminodibenzyl or cycloheptadiene structure which do not inhibit MAO are also effective antidepressant drugs (refs. 1–3 and unpublished work of J. M. Davis, G. L. Klerman and J. J. Schildkraut), and seem to act by inhibiting the re-uptake inactivation of noradrenaline4–7 and potentiating its effects in the brain.