L. Chiosa, V. Niculescu, C. Bonciocat
Nov 1, 1965
Citations
0
Influential Citations
12
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract The effect pretreatment with a number of amino acids and derivatives on mortality of mice injected intraperitoneally with 560–580 mg/kg NH 4 Cl ( ld 70–90 ). Significative protection was produced by N-acetyl-glutamate, N-acetyl-aspartate, N-carbamyl-glutamate and N-carbamyl-aspartate administered in doses of 5 mM/kg, 6 mM/kg, 5 mM/kg and 6 mM/kg respectively. N-benzoyl-derivatives of glutamic and aspartic acid, N-acetyl-glycine, N-acetyl-alanine, N-carbamyl-asparagine, glutamine, asparagine, α-acetoglutarate, diacetyl and urea were inactive. In other experiments the effect of these active compounds upon blood ammonia was studied in rats given a sublethal dose of NH 4 Cl (320 mg/kg). Ammonia estimations performed 15 min after NH 4 Cl administration showed a significant decrease in the blood ammonia level. The mechanism of the protective action is discussed in relation to the urea cycle and to pyrimidine and glutamine synthesis.