J. Castillo, T. Morales, V. Sanchez
Nov 16, 1963
Citations
3
Influential Citations
28
Citations
Journal
Nature
Abstract
PIPERAZINE is the drug most commonly used for the treatment of ascariasis, in preference to other anthelmintics, because it produces a flaccid paralysis of the parasites1 rather than hyperactivity. Though no direct evidence was available, it was suggested that such paralysis might be due to a curare-like effect, since piperazine prevents the stimulating action of acetylcholine on Ascaris muscle2.