C. Bounthanh, L. Richert, J. Beck
Nov 1, 1983
Citations
0
Influential Citations
30
Citations
Quality indicators
Journal
Planta medica
Abstract
Valtrate, didrovaltrate and deoxido-didrovaltrate were compared for toxicity on cultured rat hepatoma cells (HTC strain) and for their effects on the synthesis of DNA and proteins. Despite lacking the epoxide function in C 8 -C 11 position in its molecular structure, deoxido-didrovaltrate has a similar cytotoxicity to didrovaltrate. The toxicity of both these drugs is two times lower than that of valtrate. Incorporation tests with 3 H-thymidine and 3 H-leucine on cultured HTC cells revealed that a low dose of valtrate, rapidly and extensively inhibits the synthesis of both DNA and proteins. Didrovaltrate and deoxido-didrovaltrate have the same effect, but at double the dose.