N. M. Gelder
Sep 1, 1969
Citations
0
Influential Citations
21
Citations
Quality indicators
Journal
Journal of Neurochemistry
Abstract
Abstract— The action of hydrazinopropionic acid in vivo on the metabolism of amino acids in the CNS of mice was studied over a period of 24 hr. At 82 μmoles/kg, a transient fourfold rise in the levels of tyrosine occurred followed by a more moderate and prolonged increase in the levels of GABA. When the dose of hydrazinopropionate was raised to 123 μmoles/kg, the changes in the levels of tyrosine were identical with those at the lower dose, while levels of GABA rose further before reaching a steady state. Levels of glutamate decreased concomitantly. In addition, the concentrations of alanine, β‐aminoisobutyric acid and an unknown compound tended to rise. A doubling of the dose to 246 μmoles/kg enhanced the effects obtained with the lower doses but did not produce any new changes in the patterns of amino acids of the CNS.