L. Chahl, S. O'donnell
Jul 1, 1968
Citations
0
Influential Citations
8
Citations
Journal
British journal of pharmacology and chemotherapy
Abstract
Orciprenaline and protokylol are two bronchodilators related in structure to isoprenaline and used clinically in the treatment of asthma. They have advantages over isoprenaline and adrenaline in their longer duration of action and greater stability which allows oral administration (Spitzbarth & Albers, 1961; Von Jacobi, Koch & Schleusing. 1963). The chemical structures of isoprenaline, orciprenaline and protokylol are illustrated in Fig. 1. Orciprenaline resembles isoprenaline except that the hydroxyl groups on the ring are in the 3 and 5 positions. Protokylol is a catecholamine with a larger group than isopropyl substituted on the nitrogen atom. Orciprenaline and protokylol are reported to act purely on 8-adrenoreceptors (Engelhardt, Hoefke & Wick, 1961; Von Jacobi et al., 1963; Shanks, Brick, Hutchison & Roddie, 1967). Few quantitative studies of the effects of /3-adrenoreceptor blocking