I. Chouroulinkov, A. Gentil, B. Tierney
1977
Citations
1
Influential Citations
56
Citations
Quality indicators
Journal
Cancer Letters
Abstract
Summary 7-Methylbenz(a)anthracene and four related dihydrodiol metabolites were tested for their abilities to initiate tumour formation on mouse skin. A single application (25 μg) of the hydrocarbon or of the related 1,2-, 3,4-, 5,6- and 8,9-diols was made to the dorsal skin of CDI mice and papilloma formation promoted by thrice-weekly applications of 12-O-tetradecanoyl-phorbol-13-acetate. The 3,4-dihydrodiol was the most active compound tested, 7-methyl-benz(a)anthracene and the 8,9-diol were less active and the 1,2- and 5,6-diols were almost inactive. These results support the conclusion that, with 7-methyl-benz(a)anthracene, the active diol-epoxide is 3,4-dihydro-3,4-dihydroxy-7-methylbenz(a)anthracene 1,2-oxide.