Y. Kaneko, M. Yatsuzuka, Y. Endo
May 29, 1981
Citations
0
Influential Citations
13
Citations
Quality indicators
Journal
Biochemical and biophysical research communications
Abstract
Summary Teleocidin from Streptomyces caused rapid aggregation of human lymphocytes. Lymphocyte fractionation experiment demonstrated that the cell aggregation occurred preferentially in T-enriched lymphocytes. Teleocidin had a mitogenic effect on both T- and B-enriched lymphocytes, but had no stimulatory effect on the immunoglobulin synthesis. The effects of teleocidin on lymphocyte subpopulations resembled those of 12-0-tetradecanoylphorbol-13-acetate(TPA), while differences existed between teleocidin and lectins in stimulating functions of human lymphocytes. These observations suggest that experiments comparing the effects of tumor promoters and lectins may help to understand the mechanism of action of tumor-promoting teleocidin.