A. Bassil, R. Borman, E. Jarvie
May 1, 2008
Citations
4
Influential Citations
80
Citations
Quality indicators
Journal
British Journal of Pharmacology
Abstract
Background and purpose: Lubiprostone (Amitiza), a possible ClC‐2 channel opener derived from prostaglandin E1 and indicated for the treatment of constipation, increases chloride ion transport and fluid secretion into the intestinal lumen. As lubiprostone may also directly modulate gastrointestinal motility, we investigated its actions and the possible involvement of prostaglandin EP receptor activation on rat and human isolated gastrointestinal preparations.