H. Collier, M. Potter, E. P. Taylor
Mar 1, 1953
Citations
0
Influential Citations
3
Citations
Journal
British journal of pharmacology and chemotherapy
Abstract
Buttle (private communication) observed that decamethylene bisisoquinolinium bromide (Compound No. 7, Collier and Taylor, 1949), which had been prepared in a research programme on neuromuscular blocking agents, possessed considerable antibacterial activity. It was therefore interesting to inquire how far the antibacterial activities of bisisoquinolinium salts were influenced by alterations in chemical structure, particularly by those factors that had been found to affect neuromuscular blocking activity. The effect of reduction of the heterocyclic nucleus was examined by comparing Compounds 7 and 8 and that of introduction of methoxyl groups by comparing Compounds 8, 15, and 20 (Taylor and Collier, 1950, 1951). In order to examine the effect of variations in length of the polymethylene chain we prepared a series of polymethylene bisisoquinolinium salts of general formula (I), where n=8-14,