Jong‐Sang Kim, Hyo-Jung Kim, C. Jung
Apr 1, 2011
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Influential Citations
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Journal
The FASEB Journal
Abstract
Acer nikoense MAXIM. has been reported to contain various phenolic compounds and to be used as a folk medicine for protection against hepatic diseases and eye disorder in Japan and China. However, it remains unknown whether acerogenin C, a diarylheptanoid constituent of the maple Acer nikoense MAXIM., possesses estrogenic activity. In the present study, the estrogenic activity of acerogenin C was evaluated by measuring yeast‐based estrogen receptor‐binding activity and its effect on pS2 expression and MCF‐7 cell proliferation (E‐screen assay). Acerogenin C significantly stimulated the proliferation of ER‐positive MCF‐7 cells and showed high affinity to estrogen receptor (ER)‐beta and ER‐alpha. The compound also caused the increased pS2 expression and alkaline phosphatase activity in SaOS‐2 cells. In conclusion, acerogenin C showed significant estrogenic activity and may be used as an agent for preventing or treating postmenopausal complications such as hot flash and osteoporosis.