A. Burkman
1973
Citations
0
Influential Citations
14
Citations
Quality indicators
Journal
Neuropharmacology
Abstract
Abstract 2-Amino-5,6-dihydroxy-1,2,3,4-tetrahydronaphthalene, 2-methylamino-5,6-dihy-droxy-1, 2,3,4-tetrahydronaphthalene and 2-dimethylamino-5,6-dihydroxy-1,2,3,4-tetrahydro-naphthalene were all found to be potent emetics in dogs; potency increasing with additional N-Substitution. The methyl and dimethyl derivatives were more active than the reference standard apomorphine. On the other hand, the compounds did not provoke compulsive behavioral activities in either mice or pigeons, a fact which disrupts the pattern of parallelism that had previously been established.